abstract：:Epidemiological studies often use age-of-first-admission from psychiatric case registers to estimate age-of-onset in schizophrenia. Retrospective, interview-based methods have shown that there is a delay between onset of symptoms and eventual contact with psychiatric services, and that this delay can vary both among i...

journal_title：Schizophrenia research

authors： Welham JL,Pemberton MR,McGrath JJ

更新日期：1996-05-01 00:00:00

abstract：:Interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha and the soluble interleukin-2 receptor were measured in the serum of 34 healthy controls and 48 patients with chronic schizophrenia using ELISA sandwich assays. No differences were found between the controls and patients. ...

journal_title：Schizophrenia research

authors： Baker I,Masserano J,Wyatt RJ

更新日期：1996-05-01 00:00:00

abstract：:Neuropsychological performance in 20 chronic schizophrenic patients was contrasted to 25 Parkinson's disease, 12 Huntington's disease patients and 26 normal controls on measures shown to be sensitive to subcortical dysfunction. Some overlap was observed in the performance of the schizophrenic and basal ganglia groups ...

journal_title：Schizophrenia research

authors： Hanes KR,Andrewes DG,Pantelis C,Chiu E

更新日期：1996-05-01 00:00:00

abstract：:Few studies have used self-administered symptom scales as outcome measures with individuals who have schizophrenia. However, with the increase in community-based treatment for the serious and persistently mentally ill and the emphasis on client empowerment, their ability to monitor and report symptoms needs to be asse...

journal_title：Schizophrenia research

authors： Hamera EK,Schneider JK,Potocky M,Casebeer MA

更新日期：1996-05-01 00:00:00

abstract：:A case-control study was conducted in Singapore, in order to examine a proposed association between schizophrenia and the HLA DQB1 gene locus. The probands were male inpatients of Chinese ethnicity with schizophrenia (ICD-10 criteria, n = 102) and the controls were adults matched for gender and ethnicity (n = 111). Po...

journal_title：Schizophrenia research

authors： Nimgaonkar VL,Rudert WA,Zhang XR,Tsoi WF,Trucco M,Saha N

更新日期：1995-12-01 00:00:00

abstract：:It has been proposed that certain psychotic symptoms associated with schizophrenia reflect a deficit in the ability to appreciate other people's mental states (Frith, 1992). This notion is tested using a newly devised task examining the capacity to infer intentions behind indirect speech. The findings support the noti...

journal_title：Schizophrenia research

authors： Corcoran R,Mercer G,Frith CD

更新日期：1995-09-01 00:00:00

abstract：:Psychiatric case records from Eaton and Weil's 1950-53 study of the Hutterites were rediagnosed using DSM-III-R criteria. The results confirmed that the Hutterites have a very low prevalence of both schizophrenia (0.9 per 1000) and bipolar disorder (0.6 per 1000). Genetic and/or environmental explanations are both pos...

journal_title：Schizophrenia research

authors： Torrey EF

更新日期：1995-08-01 00:00:00

abstract：:The intracellular enzyme phospholipase A2 (PLA2) plays an essential role in the breakdown of membrane phospholipids, which regulate the physicochemical properties of the cell membrane. In the brain PLA2 has been reported to influence receptor function and signal transduction. Regarding dopaminergic neurons, data from ...

journal_title：Schizophrenia research

authors： Gattaz WF,Schmitt A,Maras A

更新日期：1995-07-01 00:00:00

abstract：:We tested the hypothesis that the expression of schizophrenic psychopathology is dependent on the stage of adolescent development. The study had a retrospective design, using high-quality case-note material of cases of schizophrenia at first admission. Patients with onset of illness between the age of 11 and 21 years ...

journal_title：Schizophrenia research

authors： Galdos P,van Os J

更新日期：1995-01-01 00:00:00

abstract：:Levels of the histamine metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), and metabolites of other aminergic transmitters and of norepinephrine were measured in cerebrospinal fluid of 36 inpatients with chronic schizophrenia and eight controls. The mean t-MH level from controls was...

journal_title：Schizophrenia research

authors： Prell GD,Green JP,Kaufmann CA,Khandelwal JK,Morrishow AM,Kirch DG,Linnoila M,Wyatt RJ

更新日期：1995-01-01 00:00:00

abstract：:In order to test the hypothesis that a poor performance in the Wisconsin test (WCST) may be an indicator of liability to schizophrenia, we compared the WCST performances of patients with DSM III-R schizophrenia, normal controls, and patients with schizotypal personality disorder (SZT PD). While schizophrenic patients ...

journal_title：Schizophrenia research

authors： Battaglia M,Abbruzzese M,Ferri S,Scarone S,Bellodi L,Smeraldi E

更新日期：1994-12-01 00:00:00

abstract：:The distribution of schizophrenia in families supports the hypothesis of heritable risk factors in schizophrenia, but there is as yet no identification of an inherited neurobiological defect. Human embryonic brain tissue fragments, derived from first trimester abortions, can be transplanted into rat hosts, where they ...

journal_title：Schizophrenia research

authors： Freedman R,Strömberg I,Nordström AL,Seiger A,Olson L,Bygdeman M,Wiesel FA,Granholm AC,Hoffer BJ

更新日期：1994-10-01 00:00:00

abstract：:Two reaction time (RT) paradigms were used to study clozapine's effects on sustained and selective attention compared to fluphenazine and placebo in 25 chronic schizophrenic patients. Sensory dominance was studied via simple and choice RTs to lights and tones, and on double-stimulus trials in which the two stimuli wer...

journal_title：Schizophrenia research

authors： Zahn TP,Pickar D,Haier RJ

更新日期：1994-09-01 00:00:00

abstract：:The incidence of cancer was studied in a cohort of all first admitted 9156 patients in Denmark with a diagnosis of schizophrenia in the period 1970-1987. The overall incidence of cancer was reduced particularly in the males. Adjustment for the smoking habits of psychiatric patients enhanced this risk reduction. Fewer ...

journal_title：Schizophrenia research

authors： Mortensen PB

更新日期：1994-06-01 00:00:00

abstract：:Schizophrenia may result from the concerted action of several pathophysiological factors. This pilot study compared the distribution of measurements of three such putative factors in 11 schizophrenics and their siblings: a neurophysiological deficit in auditory sensory gating, diminished hippocampal volume, and increa...

journal_title：Schizophrenia research

authors： Waldo MC,Cawthra E,Adler LE,Dubester S,Staunton M,Nagamoto H,Baker N,Madison A,Simon J,Scherzinger A

更新日期：1994-05-01 00:00:00

abstract：:Using the fluorescent probe DPH (1,6-diphenyl-1,3,5-hexatriene), steady-state anisotropy (rs) values were determined in red blood cell (RBC) ghost membranes of schizophrenic patients before (n = 26) and after (n = 16) haloperidol withdrawal, and age- and sex-matched normal controls (n = 22). Patients on haloperidol we...

journal_title：Schizophrenia research

authors： Yao JK,van Kammen DP

更新日期：1994-02-01 00:00:00

abstract：:Eleven acutely psychotic patients with schizophrenia or schizoaffective disorder underwent a 5-7 day drug-washout period (with lorazepam allowed) prior to participating in a 6-week controlled dose haloperidol trial. Patients were evaluated longitudinally with clinical ratings and with plasma measures of the catecholam...

journal_title：Schizophrenia research

authors： Green AI,Alam MY,Boshes RA,Waternaux C,Pappalardo KM,Fitzgibbon ME,Tsuang MT,Schildkraut JJ

更新日期：1993-06-01 00:00:00

abstract：:Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four nor...

journal_title：Schizophrenia research

authors： Wu J,Buchsbaum MS,Moy K,Denlea N,Kesslak P,Tseng H,Plosnaj D,Hetu M,Potkin S,Bracha S

更新日期：1993-03-01 00:00:00

abstract：:Haloperidol and reduced haloperidol plasma concentrations were measured in twelve schizophrenic patients upon cessation of haloperidol decanoate (HLD) treatment. Each patient received HLD 100 mg every 4 weeks for five injections. After the fifth injection, HLD was discontinued. Haloperidol and reduced haloperidol plas...

journal_title：Schizophrenia research

authors： Chang WH,Lin SK,Juang DJ,Chen LC,Yang CH,Hu WH,Chien CP,Lam YW,Jann MW

更新日期：1993-03-01 00:00:00

abstract：:Because previous studies have shown deficits in olfactory identification for male patients with schizophrenia, either withdrawn from or receiving neuroleptic medication, the purpose of the current study was to determine if such deficits occurred in male patients who had never received neuroleptics. A sample of male (n...

journal_title：Schizophrenia research

authors： Kopala LC,Clark C,Hurwitz T

更新日期：1993-01-01 00:00:00

abstract：:Natural killer cell activity was prospectively studied in 15 patients with chronic schizophrenia and in seven patients with schizoaffective disorder, depressed type. These patients were compared to individually matched normal controls. No mean differences in natural killer cell activity between the patient groups and ...

journal_title：Schizophrenia research

authors： McDaniel JS,Jewart RD,Eccard MB,Pollard WE,Caudle J,Stipetic M,Risby ED,Lewine R,Risch SC

更新日期：1992-12-01 00:00:00

abstract：:Patients with schizophrenia demonstrate a variety of attentional impairments which have proven difficult to relate to specific neural systems. Posner et al. (1988) reported an asymmetric slowing of right visual field orienting in schizophrenia similar to that observed in patients with parietal lesions. We examined the...

journal_title：Schizophrenia research

authors： Gold JM,Randolph C,Coppola R,Carpenter CJ,Goldberg TE,Weinberger DR

更新日期：1992-09-01 00:00:00

abstract：:EEGs were recorded from 32 channels in 30 normal males, ages 16-22. Delta activity decreased throughout this age range. This decrease was greatest in the left frontal and temporal regions; no occipital lead showed this pattern. Relative EEG amplitude analysis, based on normalized maps, revealed decreases with age acro...

journal_title：Schizophrenia research

authors： Buchsbaum MS,Mansour CS,Teng DG,Zia AD,Siegel BV Jr,Rice DM

更新日期：1992-07-01 00:00:00

abstract：:The present study determined the minimal exposure time (i.e., critical stimulus duration (CSD) necessary for feature registration and recognition by normals and chronic schizophrenics. Our interest was whether the longer exposure times required by schizophrenics than by normals could be attributed to an inability of s...

journal_title：Schizophrenia research

authors： Schwartz BD,Evans WJ,Sautter F,Winstead DK

更新日期：1992-07-01 00:00:00

abstract：:A total of 57 schizophrenic patients (of which 17 were first-episode, neuroleptic naive) and 76 healthy controls were screened for anti-histone IgG antibodies using an enzyme immunoassay (ELISA). All patients had significantly higher anti-histone antibody titers than controls (t = 3.1, p less than 0.003). Previously m...

journal_title：Schizophrenia research

authors： Chengappa KN,Carpenter AB,Yang ZW,Brar JS,Rabin BS,Ganguli R

更新日期：1992-04-01 00:00:00

abstract：:The 24-h profiles of plasma melatonin and cortisol were evaluated in 7 drug-free male paranoid schizophrenics and in 7 healthy subjects matched to the patients for age, sex, body weight, height and season of testing. Blood samples were obtained at 20.00, 22.00, 24.00, 01.00, 02.00, 06.00, 08.00 and 12.00 h. Light was ...

journal_title：Schizophrenia research

authors： Monteleone P,Maj M,Fusco M,Kemali D,Reiter RJ

更新日期：1992-04-01 00:00:00

abstract：:Poly(A+) mRNA was extracted from the post-mortem brain of schizophrenics (9 subjects), unipolar depressives (5 subjects) and controls (10 subjects) and used to direct the in vitro translation of radiolabelled protein in a cell-free reticulocyte-lysate system. Protein species were analysed on two-dimensional gels. Over...

journal_title：Schizophrenia research

authors： Perrett CW,Whatley SA,Ferrier IN,Marchbanks RM

更新日期：1992-03-01 00:00:00

abstract：:T1 and T2 relaxation times were measured in ten brain regions on the right and left side in a sample of 27 schizophrenic patients and 37 normal controls. The schizophrenic patients showed a prolongation of T2 relaxation time, and to a lesser extent of T1 relaxation time, which was more predominantly localized in the r...

journal_title：Schizophrenia research

authors： Andreasen NC,Ehrhardt JC,Swayze VW 2nd,Tyrrell G,Cohen G,Ku JS,Arndt S

更新日期：1991-10-01 00:00:00

abstract：:The dopamine (DA) hypothesis of schizophrenia stated that increased DA activity is the primary cause of schizophrenia. Recently, even though increased DA activity is in fact involved in psychotic symptoms and antipsychotic drug response, it has become clear that decreased DA activity is present in remitted and chronic...

journal_title：Schizophrenia research

authors： van Kammen DP,Kelley M

更新日期：1991-03-01 00:00:00

abstract：:This paper describes an elementary deficit in sensory processing in people with schizophrenia. If paired sounds are presented to normal subjects, the response to the first sound, as measured by the P50 wave of the auditory-evoked potential, is much greater than the response to the second sound. The diminished response...

journal_title：Schizophrenia research

authors： Freedman R,Waldo M,Bickford-Wimer P,Nagamoto H

更新日期：1991-03-01 00:00:00

abstract：:The content of delusions were studied in a group of schizophrenics and affective disorder patients who had an episodic course to ascertain if the content of delusions remained similar or became dissimilar during different episodes. There were 18 schizophrenics and 30 affective disorder cases in this study. Consistency...

journal_title：Schizophrenia research

authors： Sinha VK,Chaturvedi SK

更新日期：1990-10-01 00:00:00

abstract：:Clinical improvement in psychotic symptoms is not immediate when neuroleptic treatment is commenced. Previous studies have demonstrated the development of biochemical tolerance to the effects of neuroleptics on the dopamine system. This study demonstrates a relationship between this biochemical change and the clinical...

journal_title：Schizophrenia research

authors： Cooper SJ,Leahey W,Liddle J,King DJ

更新日期：1990-07-01 00:00:00

abstract：:Social skill and role functioning were assessed in matched groups of patients with DSM-III-R schizoaffective disorder, bipolar disorder, and schizophrenia. Schizophrenics were categorized as negative syndrome or non-negative on the basis of the SANS. The negative schizophrenics were significantly more impaired on almo...

journal_title：Schizophrenia research

authors： Bellack AS,Morrison RL,Mueser KT,Wade J

更新日期：1989-07-01 00:00:00

abstract：:53 inpatients with a DSM-III diagnosis of schizophrenia were assessed in the week prior to discharge from hospital on measures of social skills performance and on severity of positive and negative symptoms. A cluster analysis based on the total positive and negative symptom scores resulted in three groups. The group w...

journal_title：Schizophrenia research

authors： Jackson HJ,Minas IH,Burgess PM,Joshua SD,Charisiou J,Campbell IM

更新日期：1989-05-01 00:00:00

abstract：:A sensitive radioimmunoassay was developed to determine the steady-state, fixed-dose pharmacokinetic profile of fluphenazine decanoate in nine outpatients. To see if neuroleptic blood levels measured by this assay correlated with a clinical event, we performed a cross-sectional study of fluphenazine blood levels in 11...

journal_title：Schizophrenia research

authors： Glazer WM

更新日期：1988-11-01 00:00:00

abstract：:The degree of cortical atrophy as revealed by computed tomographic scans was assessed in 124 patients meeting the DSM III criteria for schizophrenia and in 45 age- and sex-matched healthy controls. 21 patients, i.e., 33% of the entire sample, showed moderate to severe atrophy. The presence of atrophy was not associate...

journal_title：Schizophrenia research

authors： Vita A,Sacchetti E,Calzeroni A,Cazzullo CL

更新日期：1988-09-01 00:00:00

abstract：:In order to investigate a possible relationship between schizophrenic births and viral diseases, the birth month and year of all state hospital admissions for schizophrenia in Connecticut and Massachusetts from 1973-1974 were compared with the occurrence of reportable viral diseases for 1920-1955. Data was statistical...

journal_title：Schizophrenia research

authors： Torrey EF,Rawlings R,Waldman IN

更新日期：1988-01-01 00:00:00